Curriculum Vitae

Education:

• 1971-73 : Secondary school at Belluard at Fribourg
• 1973-78 : St. Michel college at Fribourg
• 1978-83 : Biology studies at the Science Faculty of Fribourg University
• 1983-87 : Thesis work with Dr. S.G. Clarkson at the Medical Faculty of Geneva University

Professional activities:

• 1988-90 : Postdoc at EMBL in I.W. Mattaj's group. To support this work, I was the recipient of an EMBO long term fellowship
• 1990-now : Biologist at the Medical Center Geneva University

Publications:

articles

• Mazabraud A., Scherly D., Müller F., Rungger D. and Clarkson S.G. Structure and transcription termination of a Lysine tRNA gene from Xenopus laevis Journal of Molecular Biology (1987),195, 835-845

• Etzerodt M., Vignali R., Ciliberto G., Scherly D., Mattaj I.W. and Philipson L. Structure and expression of a Xenopus gene encoding an snRNP protein (U1 70K) EMBO Journal (1988), 7, 4311-4321

• Parry H.D., Scherly D. and Mattaj I.W. "Snurpogenesis": The transcription and assembly of U snRNP components. Trends in Biological Sciences (1988), 14, 15-19

• Scherly D., Boelens W., van Venrooij W.J., Dathan N.A., Hamm J. and Mattaj I.W. Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA. EMBO Journal (1989), 8, 4163-4170

• Hamm, J., Dathan N.A., Scherly, D. and Mattaj, I.W. Multiple domains of U1 snRNA, including U1-specific protein binding sites, are required for splicing. EMBO Journal (1990), 9, 1237-1244

• Scherly D., Boelens W., Dathan N.A., van Venrooij W.J. and Mattaj I.W. Major determinants of the specificity of interaction between the small nuclear ribunucleoproteins U1A andU2B" and their cognate RNAs. Nature (1990), 345, 502-506

• Scherly D., Dathan N.A., Boelens W., van Venrooij W.J. and Mattaj I.W. The U2B" RNP motif as a site of protein-protein interaction EMBO Journal (1990), 9, 3675-3681

• Boelens W., Scherly D., Beijer R.P., Jansen E.J.R., Dathan N.A., Mattaj I.W. and van Venrooij W.J. A week interaction between the U2A' protein and U2 snRNA helps to stabilize their complex with the U2B" protein. Nucleic Acid Research (1991), 19, 455-460

• Scherly D., Kambach C., Boelens W., van Venrooij W.J. and Mattaj I.W. Concerved amino acids within and outside of the N-terminal RNP motif of the U1A snRNP protein involved in U1 RNA binding. Journal of Molecular Biology (1991), 219, 577-584

• Boelens W., Scherly D., Jansen E.J. R., Kolen K., Mattaj I.W. and van Venrooij W.J. Analysis of in vitro binding of U1A protein mutants to U1 snRNA. Nucleic Acid Research (1991), 19, 4611-4618

• Scherly D., Stutz F., Lin-Marq N. and Clarkson S.G. La proteins from Xenopus laevis: cDNA cloning and developmental expression. Journal of Molecular Biology (1993), 231, 196-204

• Scherly D., Nusspikel T., Corlet., Ucla C., Bairoch A. and Clarkson S.G. Complementation of the DNA repair defect in xeroderma pigmentosum group G cells by a human cDNA related to yeast RAD2. Nature (1993), 363, 182-185

• Samec S; Clarkson SG; Blaschak J; Chakravarti A;Morris MA; Scherly D; Antonarakis SE. Dinucleotide repeat polymorphism within ERCC5 gene. Hum Mol Genet 3: 214 (1994)

• O'Donovan A., Scherly D., Clarkson S.G. and Wood R.D. Isolation of active recombinant XPG protein, a human DNA repair endonuclease. The Journal of Biological Chemistry (1994), 239, 15965-15968

  
  

short reports:

• Scherly D., Corlet J. and Clarkson S.G. Isolation and analysisof clones for the La protein of Xenopus laevis Molecular Biology Reports (1987), 12, 244

• Hamm J., Scherly D. and Mattaj I. W. Small nuclear RNA-protein complexes Biochemical Society Transactions (1988), 16, 943-944

• Scherly D., Boelens W., Dathan N.A., Kambach C., van Venrooij W.J. and Mattaj I.W. Binding specificity determinants of U1A and U2B" proteins. Molecular Biology Reports (1990), 14, 181.182

• Boelens W., Scherly D., Mattaj I.W. and van Venrooij W.J. Analysis of the in vitro binding of A and B" snRNP proteins to U1 and U2 snRNAs using mutated A and B"proteins. Molecular Biology Reports (1990), 14, 159

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